Viagra has been used in many erectile dysfunction patients since it was approved by the FDA and sold in the United States in March 1998, and recently, it has been tried to treat female sexual dysfunction such as vaginal dryness and orgasm disorder.

History of Viagra:-

Viagra was originally developed as a treatment for angina and high blood pressure, but its effectiveness was weak, so research was stopped. During clinical trials, it was found that erectile frequency increased in target patients, so it was developed as a treatment for erectile dysfunction. However, when administered together with nitroglycerin preparations used for the treatment of angina patients, the blood pressure-lowering effect of nitroglycerin may be intensified, putting the patient at risk.

How Viagra Works?

When the human body is sexually stimulated, nitric oxide is secreted from the endothelial cells of nerve endings and blood vessels, which activates Guanylate Cyclase to increase the generation of CGMP. This CGMP relaxes the smooth muscle of the cavernous body to cause an erection. As such, CGMP, which is involved in the relaxation of the Corpus Cavernosum, is degraded by an enzyme called Phosphodiesterase (PDE) type 5. Viagra increases the concentration of CGMP by inhibiting this PDE type 5 and maintains it for a long time, and plays a role in maintaining strong and long-term erection even if a slight erection occurs by the patient’s own power.

How To Make It More Effective?

When taken, Viagra takes effect quickly in the body. When taking this drug on an empty stomach, it takes on average about 20 minutes for the drug to take effect, and the time to reach the peak plasma concentration is 30-120 minutes (average 60 minutes). On the other hand, it is estimated that if Viagra is taken after a meal, its absorption will be slowed and it will take a little longer for the effect to appear.

In particular, after ingesting a high-fat diet, the time to reach the peak plasma concentration increases by about 60 minutes, and the peak plasma concentration decreases by 29%. Often, there are patients who say that Viagra after drinking has no effect. However, alcohol itself may decrease erection, and if you consume a lot of oily food while drinking, the absorption of Viagra is inhibited as above, so it may not be effective. May be

Things To Consider Before Using Viagra:-

PDE type 5, which Viagra inhibits, is present in the digestive tract (esophagus, small intestine, large intestine), urinary system (bladder, etc.), in addition to the erectile tissue of the penis, so side effects may occur. This is because PDE type 5 is present in the smooth muscle of blood vessels at low concentrations, and Viagra dilates blood vessels, which may cause such side effects.

In addition, Viagra inhibits PDE type 6 as well as PDE type 5, although it is only 1/10 of the strength. This type 6 enzyme is an enzyme in the retina of the eye, and it is said that it can cause visual impairment in 3% of Viagra users. The symptoms include a change in color perception, increased sensitivity to light, and sometimes blurred vision, which is usually mild and disappears within minutes or hours.

Some Necessary Recommendations about Viagra:-

For patients over 65 years of age or patients with severe renal or hepatic dysfunction, the dose of Viagra should start at 25 mg because the blood concentration of Viagra increases. In addition, Viagra is administered to patients who have had a myocardial infarction or stroke within the past 6 months, hypotensive patients with resting blood pressure less than 90/50 mmhg, hypertensive patients with resting blood pressure greater than 170/100 mmhg, and patients with retinitis pigmentosa.

However, according to a recent report, the side effects of Viagra do not increase in hypertensive patients compared to normal people, and as it was originally developed as a drug for angina and high blood pressure, it is said that in the case of ischemic heart disease, it may rather have a positive effect on the heart.

Final Verdicts:-

In conclusion, it can be said that Viagra is a drug that can be safely and effectively used by patients suffering from erectile dysfunction as a result of marketing over 3 years so far, and it has contributed greatly to improving the quality of life of patients.

However, such safety and efficacy can only be achieved through proper diagnosis and prescription by a doctor, and it is believed that the monitoring of drug abuse and side effects should not be neglected at all times.

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